ESTRING is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina.

Does ESTRING provide systemic estrogen?

Systemic delivery of estradiol from ESTRING resulted in mean steady state serum estradiol estimates of 7.8, 7.0, 7.0, 8.1 pg/mL at weeks 12, 24, 36, and 48, respectively.

Is vaginal estradiol systemic?

Other vaginal estradiol products are used for treating vaginal menopause symptoms and symptoms that affect other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is directly applied.