Digoxin has a negative chronotropic action on the sinus node and decreases the cardiac rate, especially in patients with heart failure.
Is digoxin chronotropic or inotropic?
Digoxin is a positive inotropic and negative chronotropic drug 7, meaning that it increases the force of the heartbeat and decreases the heart rate. The decrease in heart rate is particularly useful in cases of atrial fibrillation, a condition characterized by a fast and irregular heartbeat.
Does digoxin have negative chronotropic effect?
Digoxin did not alter the negative chronotropic response of the heart to vagal stimulation. In contrast, digoxin reduced the positive chronotropic response to sympathetic stimulation by 40%.
