However, intradermal injection can lead to complaints of pain as if it were “torn up.” A possible drawback of intradermal BTX-A injection versus intramuscular injection is increased pain.

What hurts more intradermal or intramuscular?

Intradermal capsaicin produced more intense local pain than i.m. capsaicin in the first min (skin: 68+/-6, muscle: 51+/-6 mm VASxmin, P<0.05).

Where is the least painful place to get an injection?

Subcutaneous injections tend to be less painful than intramuscular injections because the needles are smaller and do not have to push through as much tissue. Children and people who fear needles may still have issues with these injections that can cause anxiety.