The half-life of Dexedrine is around 12 hours. While the duration of the effects of Dexedrine can be anywhere from 8 to 10 hours, it takes 12 hours for just half the amount of the drug to be eliminated from the body. It can take around five half-lives for a drug to be fully eliminated.

How long does Dexamphetamine last?

Dexedrine comes in both long- and short-acting forms. The short-acting tablet comes in 5 mg dosages. This dose usually lasts about 2 hours. The longer-acting spansule is available in 5 mg, 10 mg, and 15 mg sizes and is typically effective for 8 to 10 hours after administration.

What is the half-life of Dexamphetamine?

The average half-life of dextroamphetamine is 10 to 12 hours, but this varies considerably with urinary pH; at a urine pH less than 6.6, more than two-thirds of unmetabolized drug is excreted in the urine, whereas at a urine pH greater than 6.7, it is less than one-half.