What did Griffith inject mice with?

As part of his experiments, Griffith tried injecting mice with heat-killed S bacteria (that is, S bacteria that had been heated to high temperatures, causing the cells to die). Unsurprisingly, the heat-killed S bacteria did not cause disease in mice.

What happened when Griffith injected mice with R bacteria?

In Griffith's next experiment, he mixed the heat-killed, S-strain bacteria with live, harmless bacteria from the R strain and injected the mixture into laboratory mice. The injected mice developed pneumonia, and many died. The lungs of these mice were filled with the disease-causing bacteria.