Some transcription factors bind to a DNA promoter sequence near the transcription start site and help form the transcription initiation complex. Other transcription factors bind to regulatory sequences, such as enhancer sequences, and can either stimulate or repress transcription of the related gene.

Where do transcription regulators bind in eukaryotes?

RNA polymerase by itself cannot initiate transcription in eukaryotic cells. There are two types of transcription factors that regulate eukaryotic transcription: General (or basal) transcription factors bind to the core promoter region to assist with the binding of RNA polymerase.

Where do regulatory transcription factors bind?

Basal transcription regulation

The preinitiation complex binds to promoter regions of DNA upstream to the gene that they regulate.