To preserve tissue architecture and barrier function during both homeostasis and rapid growth, individual epithelial cells divide in a highly constrained manner.

Can epithelial cells divide easily?

Epithelial cells comprise the skin and skin-like linings that coat internal organs, giving organs a protective barrier so they can function properly. Cells turn over very quickly in epithelia. To maintain healthy cell densities, an equal number of cells must divide and die.

How often do epithelial cells divide?

The epithelium of the human colon turns over at least once per week throughout life. As cells die at the surface, they are replaced by new cell divisions. By age 60, a person has been through at least 3,000 replacement cycles, which means that some cell lineages must pass through many generations.