11–15 Nystatin is not absorbed from gastrointestinal tract when orally administered. 5 Therefore, the topical use of nystatin is considered the most common route of administration in dentistry, as systemic exposure is minimal.

Is nystatin absorbed systemically?

Nystatin is not absorbed systemically and is used orally for the treatment of intestinal candidiasis.

Does oral nystatin work systemically?

Nystatin carries no significant activity against bacteria, protozoa, or viruses. It carries significant systemic toxicity and is currently unavailable in a formula appropriate for systemic use - its efficacy is currently restricted, therefore, to topical, oral, and gastrointestinal infections.