The subiculum is a pivotal structure positioned between the hippocampus proper

and entorhinal and other cortices, as well as a range of subcortical structures. It is an under-investigated region that plays a key role in the mediation of hippocampal-cortical interaction.

What functions are associated with the subiculum?

Function. It is believed to play a role in some cases of human epilepsy. It has also been implicated in working memory and drug addiction. It has been suggested that the dorsal subiculum is involved in spatial relations, and the ventral subiculum regulates the hypothalamic-pituitary-adrenal axis.

What does the entorhinal cortex do?

The entorhinal cortex is the gateway for information entering and leaving the hippocampal formation. The entorhinal cortex is a component of the medial temporal lobe memory system, although it is increasingly believed to have a perceptual function (Baxter, 2009; Suzuki, 2009).