Bioavailability is a measurement of the rate and extent to which a therapeutically active chemical is absorbed from a drug product into the systemic circulation and becomes available at the site of action. ... If two drugs are bioequivalent, there is no clinically significant difference in their bioavailability.
What factors affect drug bioavailability?
Factors which influence bioavailability
- Drug concentration at site of administration.
- Surface area of the absorptive site.
- Drug pKa.
- Drug molecule size.
- pH of the surrounding fluid.
Is bioequivalence the same as bioavailability?
Bioequivalence is Just a comparison of the bioavailability of two identical products. ... The rate and extent of absorption is called as bioavailability. Bioequivalence is the comparison of bioavailability between two drug formulations.
