Derek Sheperd's fate was ultimately be decided in Season 11 Episode 21 “How to Save a Life.” After arriving at the scene of a car crash, Derek provides as much assistance to the victims as possible before emergency services can arrive at the scene. ... While reaching down to grab it, his car is struck by a semi-trailer.

Does Derek Shepherd die in Season 11 Episode 21?

Ultimately, Shonda Rhimes announced that Dempsey would no longer be on the show. After almost a decade in the medical drama, Derek died in Season 11, Episode 21, “How to Save a Life.”

What season and episode does Derek Shepherd die in GREY's anatomy?

Derek Shepherd dies in Season 11, Episode 21 of "Grey's Anatomy."