They check your bags, but only carry on. If they have reason to think drugs or something suspicious is being transported then they bring in dogs and actual police. Some Greyhound bus stations have security some don't.

Are there metal detectors at Greyhound stations?

Greyhound said that while it does not use metal detectors at all of its locations, its safety practices are similar to other bus companies. Drivers and terminal employees also are trained on security procedures. ... That's true even though vastly more people get on a bus, train or subway than on planes each day.

Does Greyhound weigh your luggage?

Standard-sized carry-on suitcases fit perfectly in the overhead bins on Greyhound buses. ... Unlike your carry-on, your checked bags will be weighed to make sure they are not overweight. If your bag is overweight, you might have to ship it to your destination via Greyhound Package Express.