How long after receiving the HPV vaccine does it take for the vaccine to work? The immune system takes one to two weeks to generate immunity to vaccines or infections.

Are you immune to HPV after the first shot?

More than a decade after vaccination, women who had received a single dose of human papillomavirus (HPV) vaccine continued to be protected against cervical infection with the two cancer-causing HPV types targeted by the vaccine, HPV16 and 18.

How effective is the first Gardasil vaccine?

The vaccine (Gardasil 9) is highly effective. The HPV vaccine provides almost 100% protection from nine HPV types 6, 11, 16, 18, 31, 33, 45, 52 and 58), if all doses are received at the correct intervals, and if it is given before you have an infection with these types.