Long-term potentiation (LTP) is a process in which synapses are strengthened. ... In LTP, after intense stimulation of the presynaptic neuron, the amplitude of the post-synaptic neuron's response increases. The stimulus applied is generally of short duration (less than 1 second) but high frequency (over 100 Hz).

What causes synaptic potentiation?

Long-term potentiation (LTP) is a persistent strengthening of synaptic connections induced by a brief period of high-frequency presynaptic activity. ... Parallel fiber LTP is initiated by presynaptic calcium influx through voltage-activated calcium channels.

How does long-term potentiation occur in the brain?

Long-term potentiation, or LTP, is a process by which synaptic connections between neurons become stronger with frequent activation. LTP is thought to be a way in which the brain changes in response to experience, and thus may be an mechanism underlying learning and memory.