A microcirculatory disorder is therefore defined as a consequence of autonomous and autochthonous abnormalities of vascular wall, blood, and interstitial cells and fluids, which are basically independent of the macrocirculatory abnormalities but highly effective in complicating them.

What is microcirculation therapy?

Microcirculation and hyperbaric oxygen therapy. Hyperbaric oxygen therapy (HBOT) is a clinical treatment in which a patient breathes pure oxygen for a limited period of time at an increased pressure. This therapy has been suggested to improve oxygen supply to tissues and therefore improves microcirculation [38].

What causes microcirculation?

b Microcirculatory damage can be caused by ischemia, reperfusion, inflammation, and hypoxia, resulting in endothelial and glycocalyx and RBC damage. Activation of leukocytes induces rolling, adhesion, and ultimately extravasation to the tissue, which further accelerates the inflammation.