Synaptic plasticity is change that occurs at synapses, the junctions between neurons that allow them to communicate. The idea that synapses could change, and that this change depended on how active or inactive they were, was first proposed in the 1949 by Canadian psychologist Donald Hebb.

What does the term synaptic plasticity mean?

Synaptic plasticity specifically refers to the activity-dependent modification of the strength or efficacy of synaptic transmission at preexisting synapses, and for over a century has been proposed to play a central role in the capacity of the brain to incorporate transient experiences into persistent memory traces.

What are examples of synaptic plasticity?

Another intrinsic type of synaptic plasticity is called post-tetanic potentiation (PTP). It is an extreme example of facilitation defined as a relatively persistent (minutes) enhancement of synaptic strength following a brief train of spikes (a tetanus).