Methylglyoxal, a highly reactive dicarbonyl compound, is inevitably formed as a by-product of glycolysis. ... Considering the high energy requirements (i.e., glucose) of the brain, one should expect that the cerebral glyoxalase system is adequately fitted to handle methylglyoxal toxicity.

Where is methylglyoxal formed?

In organisms, methylglyoxal is formed as a side-product of several metabolic pathways. Methylglyoxal mainly arises as side products of glycolysis involving glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. It is also thought to arise via the degradation of acetone and threonine.

What does methylglyoxal do in the body?

Methylglyoxal is its active ingredient and likely responsible for these antibacterial effects. Additionally, Manuka honey has antiviral, anti-inflammatory and antioxidant benefits. In fact, it has traditionally been used for wound healing, soothing sore throats, preventing tooth decay and improving digestive issues.