Insulin has several effects in liver which stimulate glycogen synthesis. First, it activates the enzyme hexokinase, which phosphorylates glucose, trapping it within the cell.

How is hexokinase activated?

Hexokinase activates glycoloysis by phosphorylating glucose. ... Tissues where hexokinase is present use glucose at low blood serum levels. G6P inhibits hexokinase by binding to the N-terminal domain(this is simple feedback inhibition). It competitively inhibits the binding of ATP [8].

Does insulin act on glucokinase or hexokinase?

Insulin appears to affect both glucokinase transcription and activity through multiple direct and indirect pathways. While rising portal vein glucose levels increase glucokinase activity, the concomitant rise of insulin amplifies this effect by induction of glucokinase synthesis.