Glucokinase

(hexokinase D) is a monomeric cytoplasmic enzyme found in the liver and pancreas that serves to regulate glucose levels in these organs. Glucokinase is used in the first step of the metabolism of glucose, during this step the phosphorylation of glucose by ATP generates glucose-6-phosphate and ADP.

Is hexokinase only in the liver?

Hexokinase D, an isoenzyme found only in liver, has specific properties. ... Because hexokinase D activity is not inhibited by glucose 6-phosphate, this enzyme contributes significantly to the liver's capacity to regulate blood glucose.

What is the role of hexokinase?

Hexokinase is the initial enzyme of glycolysis, catalyzing the phosphorylation of glucose by ATP to glucose-6-P. It is one of the rate-limiting enzymes of glycolysis. Its activity declines rapidly as normal red cells age. ... Hexokinase deficiency appears to be inherited as an autosomal recessive disorder.