Hyperleukocytosis can affect the accuracy of platelet, hemoglobin, and even MCV determinations. Today's hematology analyzers are quite robust, and most are able to detect unlikely results that “flag” the operator, indicating careful review of the results is needed.

What does lipemia affect?

Hematology testing interference

Lipemia interferes with hematology tests by the following mechanism by light scattering. This affects the following results: Hemoglobin and hemoglobin-related indices: Results in falsely increased absorbance readings of hemoglobin, causing a falsely high measurement.

What lab values are affected by lipemia?

Conclusion: Lipemia causes clinically significant interferences for phosphorus, creatinine, total protein and calcium measurement and those interferences could be effectively removed by ultracentrifugation.