The results confirmed that vancomycin is not metabolized in the liver and most of the vancomycin ingested in the body is excreted in the urine. The most marked loss of vancomycin was in rat liver microsomes, which was degraded 50% over approximately 6 days.

Where is vancomycin absorbed?

Nonetheless, the intraperitoneal administration of vancomycin results in the systemic absorption of 54 to 65% of a given dose in 6h and results in therapeutic blood levels (Pancorbo & Comty, 1982; Bunke et al., 1983).

How does vancomycin work in the body?

Vancomycin is in a class of medications called glycopeptide antibiotics. It works by killling bacteria in the intestines. Vancomycin will not kill bacteria or treat infections in any other part of the body when taken by mouth. Antibiotics will not work for colds, flu, or other viral infections.