In medicine and psychology, clinical significance is the practical importance of a treatment effect—whether it has a real genuine, palpable, noticeable effect on daily life.

What do you mean by clinically significant?

Definition. In medical terms, clinical significance (also known as practical significance) is assigned to a result where a course of treatment has had genuine and quantifiable effects. Broadly speaking, statistical significance is assigned to a result when an event is found to be unlikely to have occurred by chance.

What are clinically significant results?

Clinical significance, on the other hand, refers to the magnitude of the actual treatment effect (i.e., the difference between the intervention and control groups, also known as the “treatment effect size”), which will determine whether the results of the trial are likely to impact current medical practice.