Irisin improves insulin resistance and type 2 diabetes by increasing sensitivity of the insulin receptor in skeletal muscle and heart, by improving hepatic glucose and lipid metabolism and by promoting pancreatic β cell functions, and browning of white adipose tissue (86).

How do I increase my irisin levels?

Researchers uncovered that people who are sedentary produce far less irisin compared to those who exercise often. Specifically, levels are increased when people do more intense aerobic interval training. Exercise is highly recommended by doctors to fight obesity and keep the cardiovascular system running strong.

What type of exercise releases irisin?

It is well established that aerobic exercise increases circulating irisin. However, some data suggest skeletal muscle mass is a robust predictor of irisin (Huh et al. 2012) and muscle strength is associated with circulating irisin (Kim et al. 2015).