Bone formation, also called ossification, process by which new bone is produced. ... Soon after the osteoid is laid down, inorganic salts are deposited in it to form the hardened material recognized as mineralized bone. The cartilage cells die out and are replaced by osteoblasts clustered in ossification centres.

What is the purpose of ossification?

Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation.

How does ossification develop?

It begins when neural crest-derived mesenchymal cells differentiate into specialized, bone-forming cells called osteoblasts. Osteoblasts group into clusters and form an ossification center. Osteoblasts begin secreting osteoid, an unmineralized collagen-proteoglycan matrix that can bind calcium.