The direct Coombs test is used to detect antibodies that are stuck to the surface of red blood cells. Many diseases and drugs can cause this to happen. These antibodies sometimes destroy red blood cells and cause anemia .

What is difference between direct and indirect Coombs test?

The direct Coombs test is done on a sample of red blood cells from the body. It detects antibodies that are already attached to red blood cells. The indirect Coombs test is done on a sample of the liquid part of the blood (serum).

When is a direct Coombs test done?

Direct Coomb's Test

This is the test that is done on the newborn's blood sample, usually in the setting of a newborn with jaundice. The test is looking for "foreign" antibodies that are already adhered to the infant's red blood cells (rbcs), a potential cause of hemolysis.