The Clostridium botulinum bacteria are the cause of botulism. Vegetative cells of C. botulinum may be ingested. Introduction of the bacteria may also occur via endospores in a wound.

What gene causes spastic paraplegia?

Mutations in the SPG4 gene (spastin protein) are responsible for approximately 40% of autosomal dominant HSP cases. Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

What disease was spastic?

The medical term "spastic" came into use to describe cerebral palsy. The Scottish Council for the Care of Spastics was founded in 1946, and the Spastics Society, an English charity for people with cerebral palsy, was founded in 1951.