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Where Does Pyruvate Processing Occur?

Sarah Jenkins • • 6 min read
Where Does Pyruvate Processing Occur?

Pyruvate is produced by glycolysis in the cytoplasm, but pyruvate oxidation

pyruvate oxidation
Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or Oxidative decarboxylation of Pyruvate), is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex. Pyruvate oxidation is the step that connects glycolysis and the Krebs cycle.
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takes place in the mitochondrial matrix (in eukaryotes). So, before the chemical reactions can begin, pyruvate must enter the mitochondrion, crossing its inner membrane and arriving at the matrix.

What is pyruvate processing?

Pyruvate processing Each pyruvate is processed to release one molecule of CO2, and the remaining two carbons are used to form the compound acetyl CoA. The oxidation of pyruvate results in more NAD+ being reduced to NADH.

Does pyruvate processing occur in fermentation?

When oxygen is not present, pyruvate will undergo a process called fermentation. ... Fermentation does not require oxygen and is therefore anaerobic. Fermentation will replenish NAD+ from the NADH + H+ produced in glycolysis.

Sarah Jenkins
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Sarah Jenkins

Sarah Jenkins is a veteran tech journalist with over 12 years of experience covering artificial intelligence, mobile innovations, and digital ethics. Her insights have appeared in leading technology publications worldwide.