But according to the World Health Organization (WHO) Reproductive Health Library, vaginal progesterone treatment had “no evidence of effectiveness.” The WHO called for further investigations of the links between progesterone and miscarriage prevention.

How long does it take for progesterone suppositories to work?

Various routes of administering natural progesterone

It is rapidly absorbed and produces measurable serum levels within 2 to 8 hours.

How did progesterone suppositories make you feel?

Bloating, stomach/abdominal pain, nausea, breast tenderness, headache, drowsiness, mood swings, irritability, or vaginal discomfort may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.