Bleomycin is cell phase specific, having its major effects on cells in the G2 and M phases of the cell cycle. The main clinical applications of bleomycin are in the treatment of squamous cell carcinoma of the head and neck, testicular tumors, and Hodgkin's lymphoma.
Is Methotrexate cell cycle specific?
Methotrexate belongs to the class of chemotherapy drugs called antimetabolites. Antimetabolites are very similar to normal substances within the cell. When the cells incorporate these substances into the cellular metabolism, they are unable to divide. Antimetabolites are cell-cycle specific.
Which of the following anti cancer drugs is cell cycle specific?
Antimetabolites are cell cycle specific. Antimetabolites are most effective during the S-phase of cell division because they primarily act upon cells undergoing synthesis of new DNA for formation of new cells. The toxicities associated with these drugs are seen in cells that are growing and dividing quickly.
