In liver cells, it is GLUT2 which is expressed and GLUT4 is expressed at significant level in insulin-sensitive tissues (muscle cells, heart cells, adipoyctes).

Is GLUT4 expressed in liver cells?

Descriptively, GLUT 4 expression in hyperglycemic conditions showed stronger intensity in all organs or tissues compared to the normal conditions (Figure 4). In the liver, GLUT4 is expressed in the cell nucleus, cytoplasm, and plasma membrane.

Where is GLUT4 found?

GLUT4 (SLC2A4) is the insulin-responding glucose transporter, found predominantly in muscle cells and adipocytes (fat cells). After a meal, glucose that is absorbed from the digestive system and circulates in the blood now stimulates the release of insulin from the pancreas (Figure 4.10).