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How Does Cyclopyrrolone Work?
How Does Cyclopyrrolone Work?
Maya Lin-Takahashi••6 min read
The mechanism of action of the cyclopyrrolone hypnotic drug zopiclone involves allosteric modulation of the GABAA receptor
GABAA receptor
γ-Aminobutyric acid type A (GABAA) receptors, the major inhibitory neurotransmitter receptors responsible for fast inhibition in the basal ganglia, belong to the superfamily of “cys-cys loop” ligand-gated ion channels. GABAA receptors form as pentameric assemblies of subunits, with a central Cl− permeable pore.
. Zopiclone displaces the binding of [(3)H]-flunitrazepam
flunitrazepam
Blood or plasma flunitrazepam concentrations are usually in a range of 5–20 μg/L in persons receiving the drug therapeutically as a nighttime hypnotic, 10–50 μg/L in those arrested for impaired driving and 100–1000 μg/L in victims of acute fatal overdosage.
with an affinity of 28 nM, and enhances the binding of the channel blocker [(35)S]-TBPS.
Is zopiclone similar to Xanax?
Alprazolam is a triazolobenzodiazepine derivative used as a tranquilizer. Zolpidem is an imidazopyridine with marked sedative-hypnotic effect and it has the same mechanism of action like benzodiazepines. Zopiclone is a cyclopyrrolone with sedative-hypnotic effect used as hypnotic and acts like benzodiazepines.
What receptors does zopiclone work?
Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor. Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex.
Maya is a hardware enthusiast who tests and reviews smart home devices, smartphones, wearables, and audio gear. She focuses on practical consumer value and build quality.
