Phase II block
It occurs after repeated boluses or a prolonged infusion of succinylcholine. In patients with atypical plasma cholinesterase, Phase II block can develop after a single dose of the drug.
Why does Phase 2 Block occur?
Mechanism of Phase II Block
This is due to increased activity of the sodium-potassium ATPase pump, which brings potassium into the cell in exchange for sodium. The receptor does not respond appropriately to acetylcholine, and neuromuscular blockade is prolonged.
What type of drug is rocuronium?
Rocuronium is a non-depolarizing neuromuscular blocker which is widely used to produce muscle relaxation to help facilitate surgery and ventilation of the lungs in elective and emergent situations.
