GLUT3 is the most prominent glucose transporter isoform expressed in adult brain, where it tends to be preferentially located in neurones, rather than in other cell types, such as glia or endothelial cells. It is also widely distributed in other human tissues, having been detected in the liver, kidney and placenta.

What is the function of GLUT3?

GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT.

Which glut is present in brain?

GLUT3 is the most abundant glucose transporter in the brain having five times higher transport capacity than GLUT1. It is present in neuropil, mostly in axons and dendrites. Its density and distribution correlate well with the local cerebral glucose demands. GLUT5 is predominantly fructose transporter.