It may take up to 12 weeks before you feel the full benefit of dapsone gel. If your acne does not improve after 12 weeks of treatment, call your doctor.

Does dapsone work right away?

Dapsone, which was developed to treat leprosy and other skin infections, is a sulfur-based antibiotic that you'll take orally. It works quickly –- often within days –- to begin clearing up your dermatitis herpetiformis.

How long does dapsone stay in your system?

The drug is also N-hydroxylated in the liver which product is responsible for the hemodynamic adverse effects. Its half life is long, 10-50 h and the time to reach plateau is at least 8 days[2]. The drug has been used for other skin disorders also.