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Does Cck Inhibit Gastrin?

Maya Lin-Takahashi • • 6 min read
Does Cck Inhibit Gastrin?

Background: Cholecystokinin inhibits the secretion of gastrin from antral G cells

G cells
G-cells are neuroendocrine cells responsible for the synthesis and secretion of gastrin. They are primarily found in the pyloric antrum but can also be found in the duodenum and the pancreas. They secrete gastrin when stimulated directly by vagal efferent neurons as well as GRP neurons.
, an effect that is speculated to be mediated by D cells secreting somatostatin. ... Conclusion: CCK inhibits gastrin secretion independently of paracrine somatostatin secretion.

How does CCK inhibit gastric acid secretion?

After eating, gastrin levels increased fourfold compared to controls with concomitant increases in acid secretion. These results suggest that post cibum, CCK is an inhibitor of acid secretion by regulating gastrin through local somatostatin; they support the hypothesis that CCK acts as an enterogastrone.

Does CCK inhibit gastric secretion?

Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled.

Maya Lin-Takahashi
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Maya Lin-Takahashi

Maya is a hardware enthusiast who tests and reviews smart home devices, smartphones, wearables, and audio gear. She focuses on practical consumer value and build quality.