Yes. Malwarebytes works very well with Windows Security where other 3rd party antivirus programs do not.

Is Malwarebytes Windows 10 compatible?

Malwarebytes Anti-Malware Now Supports Windows 10.

Do I need Windows Defender if I have Malwarebytes?

You could use Malwarebytes Anti-Malware with real-time protection but it will replace Windows Defender.