swapoff disables swapping on the specified devices and files. When the -a flag is given, swapping is disabled on all known swap devices and files (as found in /proc/swaps or /etc/fstab).
Is Swapoff safe?
If there is not enough physical memory, swapoff will not succeed and issue a swapoff failed: Cannot allocate memory error. So also there, thanks to system design, it remains safe. However, again: it is not recommended to proceed this way: it will not provide any performance gains.
What is swap priority?
Swap pages are allocated from areas in priority order, highest priority first. For areas with different priorities, a higher-priority area is exhausted before using a lower-priority area.