Malaria infection causes haemolysis of infected and uninfected erythrocytes and bone marrow dyserythropoiesis which compromises rapid recovery from anaemia.

How does malaria cause haemolytic Anaemia?

The malaria parasites, entering the blood after an infective mosquito bite, infect red blood cells. At the end of that infection cycle, red blood cell ruptures. This process lowers the amount of red blood cells and can in a severe stage cause severe anemia.

Does malaria cause extravascular hemolysis?

Intravascular hemolysis is highly accelerated due to malaria infection (23–25). In the erythrocytic stage, the malaria parasites modify the erythrocytes (26) and degrade ∼60–80% of the total RBC hemoglobin (27, 28). Severe organ damage has been reported due to malaria infection (15, 28–34).