After an initial acclimation period, most types of contact lenses should feel comfortable all the time. You shouldn't even notice they are in your eyes. But that doesn't mean that a variety of factors can't lead to discomfort over the long haul.
Why does my contact lens feel uncomfortable?
Lens-specific causes of contact lens discomfort include the wettability of the lens material, the lens design, lens fit, wearing modality (daily wear vs. extended wear) and lens care solutions. Environmental causes include patient factors (age, use of medications), tear film stability and ambient humidity.
Are contacts uncomfortable at first?
The first time you try on contact lenses, it may be difficult and feel a bit uncomfortable. However, after wearing them a few times, they should feel completely comfortable, as if they are part of your eyes.