The prefrontal cortex (PFC), as a significant nerve center of thinking and behavior regulation in the brain, is also associated with depression [47].

What part of the brain is responsible for depression?

The main subcortical limbic brain regions implicated in depression are the amygdala, hippocampus, and the dorsomedial thalamus. Both structural and functional abnormalities in these areas have been found in depression.

Is the prefrontal cortex responsible for mood?

The prefrontal cortex appears to play a critical role in the uniquely human capacity to modulate emotions. Individual differences in amygdala function also appear to affect certain parameters of emotional reactivity or emotional traits.