Beta-lactamases are enzymes (EC 3.5. 2.6) produced by bacteria that provide multi- resistance to β-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase.

Where is beta-lactamase found in the cell?

Gram-positive bacteria that make beta-lactamase excrete the enzyme into the extracellular space. Gram-negative bacteria excrete beta-lactamase into the periplasmic space located between the cytoplasmic membrane & the outer membrane, where the cell wall is located.

Where is the enzyme beta-lactamase made?

Beta-lactamase is a type of enzyme (EC 3.5. 2.6) produced by some bacteria that is responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins, cephamycins and carbapenems. These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam.