Benadryl (diphenhydramine) is a brand-name, over-the-counter medication that's classified as an antihistamine. It's used to help relieve symptoms of hay fever (seasonal allergies), other allergies, and the common cold, as well as itchy skin due to insect bites, hives, and other causes.

When did Benadryl become OTC?

Brompheniramine and chlorpheniramine became the first nonprescription antihistamines when the FDA approved their OTC sale in 1976. Dexbrompheniramine and triprolidine followed in 1982, diphenhydramine (Benadryl) in 1985, doxylamine in 1987, and clemastine (Tavist) and dexchlorpheniramine in 1992.

Is Benadryl behind the counter?

Currently, Benadryl is approved for sale without a prescription in locations where a pharmacist is present. This means that it can be sold in pharmacies and certain grocery stores, but not in convenience stores or gas stations.