Background. Histamine has been known to cause a vascular type headache for almost a hundred years. Research has focused on antihistamines as a possible treatment and histamine as a migraine provoking agent but there has been little interest in this field for the last 25 years.

What is a histamine headache?

Cluster headaches may also be known as histamine headache, red migraine, Horton's headache, and cephalalgia or sphenopalatine neuralgia. The headache periods can last several weeks or months, and then disappear completely for months or years leaving considerable amounts of pain-free intervals between series.

Do antihistamines help with headaches?

To treat your sinus headache, start with an over-the-counter (OTC) antihistamine. Histamine is a substance released during an allergic reaction; it causes swelling of the mucous membranes and mucus production. Antihistamines block the action of histamine.