Emetine is used for the treatment of amebiasis

and is a component of ipecac syrup. Emetine is both myotoxic and cardiotoxic. It has been shown to cause mitochondrial and myofibrillar change that can lead to myofiber necrosis. CK is usually elevated but can be normal in some patients with emetine-induced myopathy.

What is the mode of action of emetine?

The mechanism of action of emetine consists of the blockage of protein synthesis in eukaryotic (but not in prokaryotic) cells. It inhibits the process of polypeptide chain formation. Protein synthesis is inhibited in parasite and mammalian cells, but not in bacteria.

What type of alkaloid is emetine?

Abstract: Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug.