The PCT is responsible for reabsorbing most of the glucose, amino acids, and small peptides that enter the ultrafiltrate (Berry and Rector 1991). The PCT contains numerous secondary active, sodium-coupled transporters for glucose (SGLT2) and amino acids (Silbernagl and Gekle 2008; Silverman 2008).

What substances are reabsorbed in the PCT?

About 67 percent of the water, Na⁺, and K⁺ entering the nephron is reabsorbed in the PCT and returned to the circulation. Almost 100 percent of glucose, amino acids, and other organic substances such as vitamins are normally recovered here.

What is the function of PCT?

The PCT regulates pH of the filtrates by exchanging hydrogen ions in the interstitium for bicarbonate ions in the filtrate. It is also responsible for secreting organic acids such as creatinine and other bases into the filtrate. Proximal convoluted tubule regulate the pH of the filtrate in the kidneys.