Bioavailability is a key indicator of drug absorption. It represents the administered dose fraction which achieves success in reaching the systemic circulation when administered orally or through any other extravascular dosing route.

What is the use of bioavailability?

Bioavailability is a term used to describe the percentage (or the fraction (F)) of an administered dose of a xenobiotic that reaches the systemic circulation. Bioavailability is practically 100% (F = 1) following an intravenous administration.

What is the importance of bioavailability study?

The importance of bioavailability studies lies in testing whether an active pharmaceutical ingredient can reach systemic circulation and its intended site of action while minimizing undesired off-target side effects.