Its lineage means that pomelo contains many of the same compounds as grapefruit. One or more substances in grapefruit and grapefruit juice block the action of an enzyme called cytochrome P-450 3A4 (CYP3A4). This enzyme breaks down a wide array of medications, including atorvastatin (Lipitor).

Can you have pomelo with medication?

Be mindful that other citrus fruits might also interact with lovastatin, atorvastatin, and simvastatin. The list includes tangelos, pomelos, bitter oranges, and Seville oranges. These foods can also affect how your body metabolizes the medication.

Is it safe to eat pomelo when taking statins?

Seville oranges, limes, and pomelos also contain this chemical and should be avoided if you're taking statins.