Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors, such as telomere erosion, DNA damage, oxidative stress, and oncogenic activation, and it is thought to be an antitumor mechanism.

Why does senescence happen?

In adult tissues, senescence is triggered primarily as a response to damage, allowing for suppression of potentially dysfunctional, transformed, or aged cells. The aberrant accumulation of senescent cells with age results in potential detrimental effects.

Which process occurs in senescence?

Senescence, the cessation of cell division and permanent withdrawal from the cell cycle, is a process that occurs throughout the lifespan — during embryogenesis, growth and development, tissue remodeling, and in wound healing.