Furthermore, an updated meta-analysis has recently shown that among transdermal oestrogen users, there was no change in VTE risk in women using micronized progesterone, whereas norpregnanes derivatives were associated with increased VTE risk.

Does progesterone increase DVT risk?

While progestin in the higher doses used to treat abnormal vaginal bleeding has been shown to increase the risk of thrombosis five- to six-fold, progestin in the doses used in contraceptives has NOT been shown to increase the risk of deep vein thrombosis or pulmonary embolism.

Does progestin increase risk for VTE?

Most Progestin-Only Contraceptives Do Not Increase Venous Thromboembolism Risk. Compared with women who do not use hormonal contraception, most women who take progestin-only contraception are not at increased risk for venous thromboembolism, according to the results of a new meta-analysis.