Endogenous pyrogens are substances, which originate inside the body and which are capable of inducing fever by acting on the hypothalamic thermoregulatory centre. IL-1, tumour necrosis factor (TNF) and interferon (INF) are endogenous of albumin and transferrin decreases.

What is an exogenous pyrogen example?

An example of exogenous pyrogen is the lipopolysaccharide, which is a component of the cell wall of certain gram-negative bacteria. When it binds to a lipopolysaccharide-binding protein of the immune cell, it forms a complex that binds in turn to a CD14 receptor of a macrophage.

What releases endogenous pyrogens?

Endogenous pyrogens are produced by immune cells such as neutrophils, macrophages and lymphocytes as well as by endothelial cells, astrocytes and glial cells in response to exposure to exogenous pyrogens.